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Charcot-Marie-Tooth disease (CMT) is caused by mutations (faults) in genes that cause the peripheral nerves to become damaged.
The peripheral nerves are a network of nerves that run from the brain and spinal cord (the central nervous system). They carry impulses to and from the rest of the body, such as the limbs and organs, and are responsible for the body's senses and movements.
A peripheral nerve is similar to an electrical cable, and is made up of two parts:
In some types of CMT, faulty genes cause the myelin sheath to disintegrate. The axons become damaged without this protection, which affects the transmission of messages between the brain and the muscles and senses. This leads to muscle weakness and numbness.
In other types of CMT, the axons are directly affected and don't transmit electrical signals at the normal strength. This means muscles and senses are understimulated, leading to symptoms of muscle weakness and numbness.
A child with CMT may have inherited the genetic fault responsible for the disease from just one or both of their parents.
There's no single faulty gene that causes CMT. The many varieties of CMT are caused by different genetic mutations and the faulty genes can be inherited in several different ways.
Autosomal dominant inheritance of CMT occurs when one copy of a mutated gene is enough to cause the condition. If either parent carries a faulty gene, there's a 50% chance the condition will be passed on to each child they have.
Autosomal recessive inheritance of CMT occurs when two copies of the defective gene are needed to cause the condition. You inherit one copy from each parent. As your parents only have one copy of the gene, they don't develop CMT themselves.
If both you and your partner are carriers of the autosomal recessive CMT gene, there's a:
If only one parent has the autosomal recessive gene, your children won't develop CMT. However, there's a 50% chance each child will be a carrier.
In X-linked inheritance, the mutated gene is located on the X chromosome and passed from mother to son. Chromosomes are the parts of cells that carry your genes.
Men have XY sex chromosomes. They receive the X chromosome from their mother and the Y chromosome from their father. Women have XX chromosomes. They receive one X chromosome from their mother and the other X chromosome from their father.
A woman with the defective X chromosome will usually have no or very mild symptoms because the other healthy X chromosome counters the effect of the defective one. However, there's a 50% chance she'll pass on the defective gene to her son and that he'll develop CMT.
If a woman with the defective X chromosome only has daughters, CMT can skip a generation until one of her grandsons inherits it.
There are many different types of CMT that are all caused by different mutations (changes) in your genes.
The main types of CMT are:
You can read more about the classification of CMT on CMT UK.